This Gene Mutation Breaks the Immune System. Why Has It Survived?

In Greenland in January 2021, a child just under two years old was sick—very sick. And his doctors couldn’t figure out why. He was feverish, vomiting, having seizures. Meningitis was suspected to be the cause; a tuberculosis diagnosis was also being tossed around. The child was transferred to Copenhagen—to Rigshospitalet, the largest hospital in Denmark—for further evaluation.

By March, the child’s doctors were no closer to figuring out why he wasn’t getting better. So they reached out to Trine Mogensen, a professor of immunology at Aarhus University in Denmark. “It was really unclear what this infection was. And there was no evidence of bacterial infection or tuberculosis,” Mogensen says. Stumped,

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