The intense reaction of one of the lungs’ guardians against infection may help explain why COVID-19 can become severe.
The guardians, immune cells called interstitial macrophages, patrol lung tissue. These cells can be infected in a big way by SARS-CoV-2, researchers report online April 10 in the Journal of Experimental Medicine. Overwhelmed by the virus’ onslaught, the cells’ extreme inflammatory response may contribute to the development of pneumonia, a disease that damages the lungs and makes breathing difficult.
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