A simple shift in schedule could make cancer immunotherapy work better

The idea that cancer treatment might work better at certain times of day has circulated for decades but has rarely faced rigorous clinical testing.

Now, a randomized trial of 210 people with advanced lung cancer affirms that timing really matters, researchers report February 2 in Nature Medicine.

The study is the first controlled trial to examine whether the timing of immune therapy affects patient outcomes, offering the strongest evidence yet that circadian biology — the body’s internal clock — can shape how well cutting-edge cancer drugs mobilize the immune system against tumors.

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