Some people have never gotten COVID-19. An obscure gene may be why

Those who’ve dodged COVID-19 for more than four years may have a newly discovered immune response to thank.

In a study that intentionally infected volunteers with the coronavirus, participants with elevated activity of a little-studied immunity gene called HLA-DQA2 didn’t get a sustained infection after exposure to SARS-CoV-2, researchers report June 19 in Nature. The study offers an unprecedentedly detailed look at how the immune system responds to the coronavirus, and how variation in that response could explain why some people get sick while others don’t.

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