Over time, they refined TDI-11861. In mice, the drug didn’t appear to interfere with sexual functioning or cause any side effects. And most importantly, the sperm were normal again a day later.
Of course, there is a big caveat: Mice are not people. But humans also have the sAC enzyme, and in males, it’s also involved in sperm movement. Buck and Levin are reassured that the strategy might be safe in people by another team’s report from 2019, which described two infertile men with mutations in the gene that makes sAC. The men were otherwise healthy, except for having a higher risk of kidney stones. (Mice bred without this gene have
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