A gene involved in setting cholesterol levels may also determine whether breast cancer spreads to other parts of the body.
A variant of the PCSK9 gene drives the spread of breast cancer, but a lab-made antibody already approved to treat high cholesterol may help stop the exodus, researchers report December 9 in Cell.
For years, researchers have been examining normal tissue and breast cancer tumors that had spread to other parts of the body trying — and failing — to find mutations that spur the migration, says oncologist and cancer biologist Sohail Tavazoie of the Rockefeller University in New York City. Wenbin Mei, a cancer biologist in Tavazoie’s lab,
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