Semaglutide saps mice’s motivation to run

CHICAGO — Mice love to run. But not when they’re taking semaglutide, the diabetes and weight-loss drug sold as Ozempic and Wegovy. While on the drug, mice ran less on a wheel in a cage, a new study shows.  

The results, presented October 7 at the annual meeting of the Society for Neuroscience, are preliminary. Still, the unexpected finding raises questions about whether such increasingly popular drugs, which mimic a hormone called GLP-1, might be tinkering with people’s motivation to exercise (SN: 8/29/23).

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