Clostridioides difficile is a notoriously nasty intestinal bug, with few effective treatments and no approved vaccines. But the same technology that enabled the first COVID-19 vaccines has shown early promise, in mouse experiments, against this deadly infection, which kills 30,000 people in the United States each year.
An mRNA vaccine designed to target C. difficile and the toxins it produces protected mice from severe disease and death after exposure to lethal levels of the bacterial pathogen, researchers report in the Oct. 4 Science. While it will take much more research to see whether the vaccine is safe and effective for humans, the results hint that an mRNA vaccine might
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