Some people’s genes influence how much weight they will lose and what side effects they will experience while taking GLP-1 drugs, such as Ozempic and Zepbound.
The genetic testing company 23andMe conducted a study of more than 27,000 customers who were taking GLP-1 drugs. Such drugs work by mimicking the action of GLP-1, a hormone that helps regulate blood sugar and appetite. People who carry a particular genetic variant of the GLP-1 receptor gene GLP1R lost more weight than those who don’t carry that variant, researchers report April 8 in Nature.
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