Even though the researchers only used a RBD from one version of Covid, their vaccine generated a robust polyclonal response—meaning it created multiple antibody types, rather than just one. To Saunders, this is part of the approach’s charm: Creating many antibody types is beneficial, he says, because one that is extremely effective against a certain variant might not be as effective against another. Or vice versa: A previously weak antibody could better neutralize a newer variant. “Some of those antibodies are going to be great at responding to Omicron, some will be great at responding to Alpha, some will be great at responding to Delta,” he says. And some,
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