Epigenetic ‘Clocks’ Predict Animals’ True Biological Age

A new tool from Belsky and his colleagues, introduced in 2020 and updated earlier this year, acts as an aging speedometer. In creating their Pace of Aging biomarker, they quantified the rate of change in 19 markers of organ function at four ages, compiled them into a single index, and modeled it with methylation. “We’re actually quantifying the ongoing process of age-related decline and system integrity,” Belsky said. Those who age faster by this measure die younger, he said, adding that it predicts mortality about as well as GrimAge and may forecast stroke and dementia even better.

Age-Old Question

In 2017, representatives of the Paul G. Allen Family Foundation approached Horvath

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