Phase 2 trials test a drug for both efficacy and safety, typically in hundreds of volunteers, and look for harmful or unpleasant drug reactions. A previous Phase 2 trial of an injectable hormone-based contraceptive for men was stopped in 2011 because the drug had too many side effects, including muscle pain, increased libido, acne, and depression. Its development was backed by the World Health Organization and CONRAD, a reproductive health nonprofit.
For the gel trial, side effects might include weight gain and mood issues. “There are going to be a small percentage of men that are going to have some kind of
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